Gene information
Official symbol CCL3
Official full name C-C motif chemokine ligand 3
Gene type protein-coding gene
Chromosome17q12
Alias symbolG0S19-1; LD78ALPHA; MIP-1-alpha
Previous symbolSCYA3
Gene familyChemokine ligands
Resources
Entrez Gene 6348
HGNC HGNC:10627
Ensembl ENSG00000277632
Vega OTTHUMG00000188413
UCSC uc032gca.3
GO terms: 188 records
GO Description Category LogP Number of genes Detail
GO:0001503 ossification GO Biological Processes -16.3087139 28 More
GO:0001649 osteoblast differentiation GO Biological Processes -6.81659337 21 More
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002263 cell activation involved in immune response GO Biological Processes -10.3401505 18 More
GO:0002274 myeloid leukocyte activation GO Biological Processes -20.6988408 25 More
GO:0002366 leukocyte activation involved in immune response GO Biological Processes -10.4998832 18 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002444 myeloid leukocyte mediated immunity GO Biological Processes -7.71730059 9 More
GO:0002548 monocyte chemotaxis GO Biological Processes -10.9439631 11 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002690 positive regulation of leukocyte chemotaxis GO Biological Processes -28.1480961 27 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0002761 regulation of myeloid leukocyte differentiation GO Biological Processes -12.4818724 17 More
GO:0002762 negative regulation of myeloid leukocyte differentiation GO Biological Processes -4.32673439 6 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0006816 calcium ion transport GO Biological Processes -5.55009887 27 More
GO:0006873 cellular ion homeostasis GO Biological Processes -10.3574947 26 More
GO:0006875 cellular metal ion homeostasis GO Biological Processes -10.3879696 23 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0008009 chemokine activity GO Molecular Functions -11.8970416 12 More
GO:0008047 enzyme activator activity GO Molecular Functions -1.49794348 13 More
GO:0008347 glial cell migration GO Biological Processes -5.57331468 10 More
GO:0008360 regulation of cell shape GO Biological Processes -5.20319448 20 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009636 response to toxic substance GO Biological Processes -18.1818984 46 More
GO:0010818 T cell chemotaxis GO Biological Processes -3.23941104 3 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0016301 kinase activity GO Molecular Functions -2.42130611 19 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019722 calcium-mediated signaling GO Biological Processes -11.6647584 29 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0019932 second-messenger-mediated signaling GO Biological Processes -19.1717114 46 More
GO:0022604 regulation of cell morphogenesis GO Biological Processes -5.63620747 32 More
GO:0030003 cellular cation homeostasis GO Biological Processes -9.22969208 24 More
GO:0030278 regulation of ossification GO Biological Processes -11.2759455 26 More
GO:0030279 negative regulation of ossification GO Biological Processes -7.69659659 12 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030500 regulation of bone mineralization GO Biological Processes -10.1371537 13 More
GO:0030502 negative regulation of bone mineralization GO Biological Processes -6.65436623 6 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030593 neutrophil chemotaxis GO Biological Processes -16.9449855 18 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031644 regulation of nervous system process GO Biological Processes -8.22607591 24 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032651 regulation of interleukin-1 beta production GO Biological Processes -19.7300517 34 More
GO:0032652 regulation of interleukin-1 production GO Biological Processes -24.2088254 41 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032731 positive regulation of interleukin-1 beta production GO Biological Processes -11.8061175 13 More
GO:0032732 positive regulation of interleukin-1 production GO Biological Processes -14.7376831 16 More
GO:0032760 positive regulation of tumor necrosis factor production GO Biological Processes -21.1788990 23 More
GO:0032940 secretion by cell GO Biological Processes -8.42144465 43 More
GO:0034341 response to interferon-gamma GO Biological Processes -10.8524889 26 More
GO:0034612 response to tumor necrosis factor GO Biological Processes -24.4651326 32 More
GO:0036230 granulocyte activation GO Biological Processes -5.56986570 6 More
GO:0036314 response to sterol GO Biological Processes -7.24411974 11 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042056 chemoattractant activity GO Molecular Functions -15.3237868 13 More
GO:0042063 gliogenesis GO Biological Processes -20.3412228 47 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042379 chemokine receptor binding GO Molecular Functions -11.1027858 13 More
GO:0043030 regulation of macrophage activation GO Biological Processes -14.6396218 15 More
GO:0043032 positive regulation of macrophage activation GO Biological Processes -14.1432953 16 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043087 regulation of GTPase activity GO Biological Processes -2.19988031 26 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043523 regulation of neuron apoptotic process GO Biological Processes -14.5388618 39 More
GO:0043525 positive regulation of neuron apoptotic process GO Biological Processes -3.54364153 9 More
GO:0043547 positive regulation of GTPase activity GO Biological Processes -1.94334853 20 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044403 biological process involved in symbiotic interaction GO Biological Processes -18.5885778 29 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045637 regulation of myeloid cell differentiation GO Biological Processes -9.39364926 18 More
GO:0045638 negative regulation of myeloid cell differentiation GO Biological Processes -3.67865682 7 More
GO:0045670 regulation of osteoclast differentiation GO Biological Processes -10.2566667 12 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048020 CCR chemokine receptor binding GO Molecular Functions -3.43820610 5 More
GO:0048245 eosinophil chemotaxis GO Biological Processes -7.27705643 6 More
GO:0048246 macrophage chemotaxis GO Biological Processes -8.11586193 6 More
GO:0048247 lymphocyte chemotaxis GO Biological Processes -6.64704408 8 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050795 regulation of behavior GO Biological Processes -5.81792293 14 More
GO:0050801 ion homeostasis GO Biological Processes -12.0812968 60 More
GO:0050848 regulation of calcium-mediated signaling GO Biological Processes -1.66142201 4 More
GO:0050850 positive regulation of calcium-mediated signaling GO Biological Processes -2.70063624 4 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0050918 positive chemotaxis GO Biological Processes -15.2518887 14 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051282 regulation of sequestering of calcium ion GO Biological Processes -7.93009971 22 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051702 biological process involved in interaction with symbiont GO Biological Processes -12.570571 16 More
GO:0051851 modulation by host of symbiont process GO Biological Processes -3.57446267 6 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0051924 regulation of calcium ion transport GO Biological Processes -18.2498286 49 More
GO:0051928 positive regulation of calcium ion transport GO Biological Processes -8.94961635 14 More
GO:0051930 regulation of sensory perception of pain GO Biological Processes -2.96037075 4 More
GO:0051931 regulation of sensory perception GO Biological Processes -2.96037075 4 More
GO:0055065 metal ion homeostasis GO Biological Processes -12.9426258 29 More
GO:0055074 calcium ion homeostasis GO Biological Processes -10.3600555 19 More
GO:0055080 cation homeostasis GO Biological Processes -11.5718912 30 More
GO:0055082 cellular chemical homeostasis GO Biological Processes -17.6289728 71 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0070098 chemokine-mediated signaling pathway GO Biological Processes -11.4747808 14 More
GO:0070167 regulation of biomineral tissue development GO Biological Processes -10.3239090 23 More
GO:0070168 negative regulation of biomineral tissue development GO Biological Processes -8.43961427 8 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070555 response to interleukin-1 GO Biological Processes -18.9736890 36 More
GO:0070588 calcium ion transmembrane transport GO Biological Processes -2.54626507 17 More
GO:0070723 response to cholesterol GO Biological Processes -8.11481650 11 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071346 cellular response to interferon-gamma GO Biological Processes -8.94844866 13 More
GO:0071347 cellular response to interleukin-1 GO Biological Processes -16.1002741 19 More
GO:0071356 cellular response to tumor necrosis factor GO Biological Processes -22.5666334 29 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071621 granulocyte chemotaxis GO Biological Processes -16.4324548 18 More
GO:0071674 mononuclear cell migration GO Biological Processes -16.6998600 20 More
GO:0071675 regulation of mononuclear cell migration GO Biological Processes -19.9332328 23 More
GO:0071677 positive regulation of mononuclear cell migration GO Biological Processes -15.5919825 16 More
GO:0072503 cellular divalent inorganic cation homeostasis GO Biological Processes -7.40235615 16 More
GO:0072507 divalent inorganic cation homeostasis GO Biological Processes -10.6286093 21 More
GO:0072677 eosinophil migration GO Biological Processes -7.10577702 6 More
GO:0072678 T cell migration GO Biological Processes -4.46557398 5 More
GO:0090279 regulation of calcium ion import GO Biological Processes -9.31154255 13 More
GO:0090280 positive regulation of calcium ion import GO Biological Processes -7.46129980 6 More
GO:0097305 response to alcohol GO Biological Processes -17.4096682 46 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0097530 granulocyte migration GO Biological Processes -19.1764933 21 More
GO:0097553 calcium ion transmembrane import into cytosol GO Biological Processes -4.27502414 13 More
GO:0098771 inorganic ion homeostasis GO Biological Processes -12.1048319 31 More
GO:0110149 regulation of biomineralization GO Biological Processes -10.9748263 24 More
GO:0110150 negative regulation of biomineralization GO Biological Processes -8.31494447 8 More
GO:0140352 export from cell GO Biological Processes -8.94733589 48 More
GO:0150077 regulation of neuroinflammatory response GO Biological Processes -14.4671881 13 More
GO:0150078 positive regulation of neuroinflammatory response GO Biological Processes -8.75781093 7 More
GO:1901214 regulation of neuron death GO Biological Processes -23.5458880 37 More
GO:1901216 positive regulation of neuron death GO Biological Processes -5.62852599 9 More
GO:1901623 regulation of lymphocyte chemotaxis GO Biological Processes -4.70812216 5 More
GO:1902105 regulation of leukocyte differentiation GO Biological Processes -18.8286876 32 More
GO:1902106 negative regulation of leukocyte differentiation GO Biological Processes -7.27922558 19 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -20.7768498 23 More
GO:1903706 regulation of hemopoiesis GO Biological Processes -16.2759166 33 More
GO:1903707 negative regulation of hemopoiesis GO Biological Processes -7.72888419 20 More
GO:1903975 regulation of glial cell migration GO Biological Processes -5.72938190 7 More
GO:1903977 positive regulation of glial cell migration GO Biological Processes -7.18867136 7 More
GO:1903978 regulation of microglial cell activation GO Biological Processes -3.92689699 4 More
GO:1904139 regulation of microglial cell migration GO Biological Processes -5.71303575 4 More
GO:1904141 positive regulation of microglial cell migration GO Biological Processes -6.00954872 4 More
GO:1905517 macrophage migration GO Biological Processes -7.27705643 6 More
GO:1905521 regulation of macrophage migration GO Biological Processes -12.9236434 12 More
GO:1905523 positive regulation of macrophage migration GO Biological Processes -10.7598894 9 More
GO:1990266 neutrophil migration GO Biological Processes -18.6358512 20 More
GO:1990868 response to chemokine GO Biological Processes -10.9019396 14 More
GO:1990869 cellular response to chemokine GO Biological Processes -10.9019396 14 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000403 positive regulation of lymphocyte migration GO Biological Processes -3.93813909 5 More
GO:2000501 regulation of natural killer cell chemotaxis GO Biological Processes -5.71303575 4 More
KEGG pathways: 8 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04062 Chemokine signaling pathway KEGG Pathway -9.12263704 17 More
hsa04620 Toll-like receptor signaling pathway KEGG Pathway -11.1460554 15 More
hsa05142 Chagas disease KEGG Pathway -21.3868632 23 More
hsa05163 Human cytomegalovirus infection KEGG Pathway -9.77103740 19 More
hsa05323 Rheumatoid arthritis KEGG Pathway -22.3868189 23 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Drug-Gene interaction
view
Related drugs: 2 records
Drug name Interaction type Source PMID View
infliximab NCI 16219708 view
nagrestipen TTD view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
C-C motif chemokine 3 proteomics left ventricular end-diastolic diameter[other] acute myocardial infarction Parissis JT et al. J Interferon Cytokine Res. 2002
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